Article

Heterocyclyl linked phenyl containing Thiazolidinediones and its Cyclic analogs as potential novel Antidiabetic agents

Abstract

Thiazolidinediones derivatives represent a vital class of organic compounds with broad biological activities for treatment of diseases such as diabetes, cancer etc. We describe here different class of synthetic heterocyclic α-glucosidase inhibitors resulting from incorporation of different fragments on desired heterocycle, from literature, which were evaluated for vast range of antidiabetic, anti inflammatory functions by successful binding interactions of molecule with enzyme which induced significant structural alterations. Kinetic studies of most active compounds in terms of selective mode of inhibition and dissociation constant were examined in order to develop an effective therapeutic strategy and management for controlling post-prandial hyperglycemia in diabetic patients. Our studies identify different novel series of potent α- glucosidase inhibitors for further investigation and new opportunities to develop antidiabetic drugs.

Keywords: α-glucosidase inhibitors, Diabetes Mellitus, Thiazolidinediones, IC50