Research article

Ameliorative Effect of Vitamin E and C on Paraquat Induced Nephrotoxicity in Rat

Abstract

The kidney is an exceptionally essential organ required for metabolic byproducts elimination in the body and when the kidney is impaired, this role is compromised. Paraquat is a poison that is known to have harmful effect in various organs. Subsequently, the point of this study was to reveal the treatment impact of vitamin E and C in paraquat poisoned kidney in rat. The rat were 200 and they were classified into 4 groups assigned as A, B, C and D. The A group was the control, B, C and D were test groups classified in light of dose of paraquat given. “A” was not treated with paraquat, B, C and D were treated with 0.02g, 0.04g and 0.06g of paraquat separately at regular intervals of 2 weeks for 3 months. Each group had subgroups assigned "0" and "VEC"; "0" subgroups were subgroups not treated with vitamin E while "VEC" were subgroups treated with 500mg of vitamin E and 2000mg/dl vitamin C. Treatment of vitamin E and C happened week after week for one month. Both vitamins and paraquat treatment happened orally. After treatment period, the rats were sacrificed and blood sample collected through cardiac puncture for urea and creatinine assay. The outcomes showed that there was no significant difference in urea levels among only paraquat treated groups yet there was a significant increase in creatinine levels among only paraquat treatment groups. There was a significant decrease in creatinine level after vitamin E and C treatment. This study has shown that vitamin E and C is capable of restoring kidney function paraquat induced nephrotoxicity in rat.

Keywords: kidney, paraquat, rat, treatment, vitamin.