Healthcare Studies

Research Article

Influence of Secretor Status on the Glucose-6-Phosphate Dehydrogenase Activity

  • By Alphonsus Ogbonna Ogbuabor, Miriam Obiageli Aniagolu, Emmanuel Sunday Onah - 29 Feb 2024
  • Healthcare Studies, Volume: 2, Issue: 1, Pages: 27 - 32
  • Received: November 30, 2023; Accepted: February 20, 2024; Published: February 29, 2024


Background: Glucose 6-phosphate dehydrogenase (G6PD) deficiency is the commonest human enzymopathy. It is particularly common in populations living in malaria-endemic areas, affecting more than 400 million people worldwide. Objective: The aim of the present study was to investigate the association of secretor status with G6PD activity. Materials and Methods: This was a cross sectional study of 120 serially recruited apparently healthy males. Secretor status of subjects were determined by the hemagglutination test while the G6PD activity was determined by the enzymatic spectrophotometric quantitation assay. Data was analyzed using the Statistical Package for Social Sciences version 23. P<0.05 was considered significant. Result: 97% of the secretors showed normal G6PD activity while 5% showed deficient G6PD activity. 22.2% of the non-secretors showed normal G6PD activity while 77.7% showed deficient G6PD activity. Conclusion: This finding suggests that non-secretion of ABH substance maybe a risk factor for reduced G6PD activity or deficiency.