Research Article

Nephroprotective Effects of Eucalyptus Camaldulensis Ethanolic Leaf Extract In Wistar Rats

Abstract

Aim: This work is aimed at investigating the effects of the ethanol leaves extract of Eucalyptus camaldulensis on serum electrolytes level of Wistar rats. Materials and Methods: Forty-five albino Wistar rats were randomly selected into 6 groups of 7 rats each. The animals in group 1 (control) were given only distilled water while those in groups 2, 3,4,5,and 6 served as a treatment group and received 150, 250, 350, 450 and 550mg/kg body weight of the extract respectively. This treatment was carried out within a 21 day period and on the 21 day, the animals were sacrificed by cardiac puncture and blood was collected into plain tubes for biochemical investigations. Results: Administrations of the extract resulted in a significant (p<0.05) decrease of potassium of 250mg/kg  (36.48±10.20), 350mg/kg (26.03±3.44), 550mg/kg (28.97±2.76) except for group 4 (73.32±21.51) and 5 (43.28±5.77) respectively when compared to the control group. Similarly, the concentration of sodium for the control group is higher than for 150mg/kg (244.63104.4), 250mg/kg (106.82 ±22.68),350mg/kg(210.63 ±113.00, and 550mg/kg (526.75±108.01) respectively except for 450mg/kg (526.75±108.01) compared to the control group. For chloride, this study showed no significant changes when compared with the control group.sub chronic administration of the extract does not show any significant changes in urea and creatinine. Conclusion: Eucalyptus camaldulensis is not toxic to the kidney at the different concentrations administered. The extract may have nephro protective effects on Wistar rats.